The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of irritable bowel syndrome−−

A double blind, placebo− controlled, randomized study.

Clinical nutrition (Edinburgh Scotland), {Clin−Nutr}, Dec 2005 (epub: 27 Jul 2005),

Niv−Eva, Naftali−Timna, Hallak−Ron, Vaisman−Nachum.
Author affiliation
The Department of Gastroenterology, Sourasky Medical Center, Meir Hospital, Tel−Aviv University, Israel.
Abstract

BACKGROUND: It was suggested that the intestinal microflora may play a role in the pathogenesis of irritable bowel syndrome (IBS). Probiotics may ease symptoms in IBS patients by changing gut microflora, reducing mucosal inflammation and exerting antibacterial effects.

AIM: To assess the short− and long−term effects of Lactobacillus reuteri administration on clinical symptoms of IBS.

METHODS: This is a double blind, placebo−controlled 6−month trial. Subjects consumed 1x10(8)cfu /tablet twice a day. The clinical severity of the IBS symptoms was evaluated by the Francis Severity score and the IBS quality−of−life score at study entry and then monthly.

RESULTS: In total, 54 subjects were randomized for treatment and 39 concluded the study. Both groups (treatment and placebo) improved significantly in all the studied parameters
with no significant differences between groups. Two parameters, constipation and passing gases, were marginally different between the main groups (P=0.0714 and 0.0971, respectively).

CONCLUSIONS: IBS symptoms did not improve with probiotic treatment with L. reuteri. A strong placebo effect and a lack of uniformity of the IBS population may have hindered a clearer demonstration of the effect.

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